The UNC-104/KIF1 family of kinesins.
نویسنده
چکیده
Most UNC-104/KIF1 kinesins are monomeric motors that transport membrane-bounded organelles toward the plus ends of microtubules. Recent evidence implies that KIF1A, a synaptic vesicle motor, moves processively. This surprising behavior for a monomeric motor depends upon a lysine-rich loop in KIF1A that binds to the negatively charged carboxyl terminus of tubulin and, in the context of motor processivity, compensates for the lack of a second motor domain on the KIF1A holoenzyme.
منابع مشابه
Molecular Cloning and Functional Studies of Neurospora crassa KIF1, a New Member of the UNC-104/KIF1 Family of Kinesin-like Proteins
KIF1, a new short member of the UNC104/KIF1-Family of Kinesins.
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ورودعنوان ژورنال:
- Current opinion in cell biology
دوره 13 1 شماره
صفحات -
تاریخ انتشار 2001